Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing

Abstract Adult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells (OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked and thereby regulated are yet to be defined. Here, we present evidence that during intramembranous bone formation...

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Bibliographic Details
Main Authors: S. Lee, L. H. Remark, A. M. Josephson, K. Leclerc, E. Muiños Lopez, D. J. Kirby, Devan Mehta, H. P. Litwa, M. Z. Wong, S. Y. Shin, P. Leucht
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-021-00139-x