Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung

Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung

Abstract Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of-function mutations affecting the quorum-sensing regulator LasR are often found in bacteria isolated from patients w...

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Bibliographic Details
Main Authors: Kelei Zhao, Xiting Yang, Qianglin Zeng, Yige Zhang, Heyue Li, Chaochao Yan, Jing Shirley Li, Huan Liu, Liangming Du, Yi Wu, Gui Huang, Ting Huang, Yamei Zhang, Hui Zhou, Xinrong Wang, Yiwen Chu, Xikun Zhou
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41704-w

Internet

https://doi.org/10.1038/s41467-023-41704-w

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