Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology

Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology

Alzheimer's disease is a neurodegenerative disease characterized by the formation of plaques composed of amyloid-β (Aβ) peptide. Vaccination of transgenic models reduced Aβ deposition and protected these mice from memory deficits. However, Phase IIa clinical trials were halted prematurely. Sinc...

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Bibliographic Details
Main Authors: Kevin A. DaSilva, Mary E. Brown, David Westaway, JoAnne McLaurin
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Aβ peptide
Alzheimer's disease
Immunization
GM-CSF
IL-4
Plaque morphology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000817

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http://www.sciencedirect.com/science/article/pii/S0969996106000817

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