Curcumin and saroglitazar attenuate diet-induced nonalcoholic steatohepatitis by activating the Nrf2 pathway and suppressing ERK1/2 signaling

Curcumin and saroglitazar attenuate diet-induced nonalcoholic steatohepatitis by activating the Nrf2 pathway and suppressing ERK1/2 signaling

Objective(s): Non-alcoholic fatty liver disease (NAFLD) is a chronic steatohepatitis disorder. If left untreated, it can progress to hepatocellular carcinoma. Several studies have shown that saroglitazar, a PPARα/γ dual agonist, and curcumin (the principal constituent of turmeric) may be effective i...

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Bibliographic Details
Main Authors: Reza Afarin, Negar Dinarvand, Hossein Azizi Dariuni, Ghazal Orak, Bahar Jaberian Asl, Reza Azizi, Azam Khedri
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2024-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
curcumin
erk1/2
nafld
nrf2
saroglitazar
Online Access:https://ijbms.mums.ac.ir/article_24179_fb064cf5242941886e2cff8769ce6294.pdf

Internet

https://ijbms.mums.ac.ir/article_24179_fb064cf5242941886e2cff8769ce6294.pdf

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