Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults

Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults

Thomas et al. test 6 ELISAs detecting IgA and IgG antibodies to whole SARS-CoV-2 spike protein, to its receptor binding domain region and to nucleocapsid protein in saliva. Across 20 household outbreaks, antibody responses are heterogeneous, but a reliable indicator of recent infection.

Bibliographic Details
Main Authors: Amy C. Thomas, Elizabeth Oliver, Holly E. Baum, Kapil Gupta, Kathryn L. Shelley, Anna E. Long, Hayley E. Jones, Joyce Smith, Benjamin Hitchings, Natalie di Bartolo, Kate Vasileiou, Fruzsina Rabi, Hanin Alamir, Malak Eghleilib, Ore Francis, Jennifer Oliver, Begonia Morales-Aza, Ulrike Obst, Debbie Shattock, Rachael Barr, Lucy Collingwood, Kaltun Duale, Niall Grace, Guillaume Gonnage Livera, Lindsay Bishop, Harriet Downing, Fernanda Rodrigues, Nicholas Timpson, Caroline L. Relton, Ashley Toye, Derek N. Woolfson, Imre Berger, Anu Goenka, Andrew D. Davidson, Kathleen M. Gillespie, Alistair J. K. Williams, Mick Bailey, Ellen Brooks-Pollock, Adam Finn, Alice Halliday, the CoMMinS Study Team
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-023-00264-2

Internet

https://doi.org/10.1038/s43856-023-00264-2

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