Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy

Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy

Abstract Background Mitochondrial autophagy maintains mitochondrial function and cellular homeostasis and plays a critical role in the pathological process of cerebral ischemia/reperfusion injury (CIRI). Whether Gypenoside XVII (GP17) has regulatory effects on mitochondrial autophagy against CIRI re...

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Bibliographic Details
Main Authors: Weijie Xie, Ting Zhu, Shuxia Zhang, Xiaobo Sun
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Gypenoside XVII
Cerebral ischemia/reperfusion injury
FOXO3A
BNIP3
Mitochondrial autophagy
Online Access:https://doi.org/10.1186/s12967-022-03830-9

Internet

https://doi.org/10.1186/s12967-022-03830-9

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