The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

Herpes Simplex Virus Type-1 (HSV-1) forms progeny in the nucleus within distinct membrane-less inclusions, the viral replication compartments (VRCs), where viral gene expression, DNA replication, and packaging occur. The way in which the VRCs maintain spatial integrity remains unresolved. Here, we d...

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Bibliographic Details
Main Authors: Michael Seyffert, Fanny Georgi, Kurt Tobler, Laurent Bourqui, Michela Anfossi, Kevin Michaelsen, Bernd Vogt, Urs F. Greber, Cornel Fraefel
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Herpes Simplex Virus Type-1
viral transcription factor
ICP4
intrinsically disordered proteins
liquid–liquid phase separation
viral replication compartments
Online Access:https://www.mdpi.com/1422-0067/22/9/4447

Internet

https://www.mdpi.com/1422-0067/22/9/4447

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