Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment

Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment

Abstract Background CD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute myeloid leukemia (AML), we found that APOC2 acts with CD36 to promote leukemia growth by activating the LYN-ERK signaling. CD36 also plays a role i...

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Bibliographic Details
Main Authors: Yiting Meng, Mateusz Pospiech, Atham Ali, Ritu Chandwani, Mary Vergel, Sandra Onyemaechi, George Yaghmour, Rong Lu, Houda Alachkar
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
CD36
Knockout
Hematopoiesis
T Cells
Acute myeloid leukemia
Mouse
Online Access:https://doi.org/10.1186/s11658-023-00455-8

Internet

https://doi.org/10.1186/s11658-023-00455-8

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