Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment
Abstract Background CD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute myeloid leukemia (AML), we found that APOC2 acts with CD36 to promote leukemia growth by activating the LYN-ERK signaling. CD36 also plays a role i...
Main Authors: | Yiting Meng, Mateusz Pospiech, Atham Ali, Ritu Chandwani, Mary Vergel, Sandra Onyemaechi, George Yaghmour, Rong Lu, Houda Alachkar |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2023-05-01
|
Series: | Cellular & Molecular Biology Letters |
Subjects: | |
Online Access: | https://doi.org/10.1186/s11658-023-00455-8 |
Similar Items
-
Extramedullary hematopoiesis in the axillary lymph node in a patient with an accelerated phase of chronic myeloid leukemia
by: Gülşah Kaygusuz, et al.
Published: (2009-03-01) -
From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression
by: Carmelo Gurnari, et al.
Published: (2021-02-01) -
Circular RNAs in Hematopoiesis with a Focus on Acute Myeloid Leukemia and Myelodysplastic Syndrome
by: Michaela Dostalova Merkerova, et al.
Published: (2020-08-01) -
The role of inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models?
by: Jun Wang, et al.
Published: (2022-08-01) -
Editorial: Transcriptional and epigenetic regulation in normal and aberrant hematopoiesis
by: Jonas S. Jutzi, et al.
Published: (2024-03-01)