Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data

Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data

Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUC<sub>IBRU</sub>) instead of trough concentration (C<sub>min,ss</sub>) because of a limited accumulation in plasma. Our objective was to identify a limited sampling stra...

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Bibliographic Details
Main Authors: Félicien Le Louedec, Fanny Gallais, Fabienne Thomas, Mélanie White-Koning, Ben Allal, Caroline Protin, Loïc Ysebaert, Étienne Chatelut, Florent Puisset
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
ibrutinib
metabolite
therapeutic drug monitoring
Bayesian analysis
pharmacokinetics
Online Access:https://www.mdpi.com/1424-8247/14/2/162

Internet

https://www.mdpi.com/1424-8247/14/2/162

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