Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A. muciniphila) with inosine in alleviating alcohol-induced liv...

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Bibliographic Details
Main Authors: Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Lanman Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Subjects:
alcoholic liver disease
Akkermansia muciniphila
inosine
gut microbiota
adenosine 2A receptor
Regulatory T Cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1355225/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1355225/full

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