Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.

Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.

Matriptase, a membrane-associated serine protease, plays an essential role in epidermal barrier function through activation of the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin. The matriptase-prostasin proteolytic cascade is tightly regulated by hepatocyte growth factor acti...

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Bibliographic Details
Main Authors: Ya-Wen Chen, Zhenghong Xu, Adrienne N H Baksh, Jehng-Kang Wang, Chiu-Yuan Chen, Richard Swanson, Steve T Olson, Hiroaki Kataoka, Michael D Johnson, Chen-Yong Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3652837?pdf=render

Internet

http://europepmc.org/articles/PMC3652837?pdf=render

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