Pathological Role of Receptor for Advanced Glycation End Products in Calcified Aortic Valve Stenosis

Pathological Role of Receptor for Advanced Glycation End Products in Calcified Aortic Valve Stenosis

Background Aortic stenosis (AS) is highly prevalent in patients with atherosclerotic cardiovascular disease. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play a pivotal role for vascular calcification in atherosclerosis. We hypothesize that the AGEs–RAGE axis could also be...

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Bibliographic Details
Main Authors: Kosuke Saku, Nobuhiro Tahara, Tohru Takaseya, Hiroyuki Otsuka, Kazuyoshi Takagi, Takahiro Shojima, Yusuke Shintani, Yasuyuki Zaima, Satoshi Kikusaki, Tomofumi Fukuda, Atsunobu Oryoji, Yuri Nishino, Takanori Matsui, Tatsuyuki Kakuma, Jun Akiba, Yoshihiro Fukumoto, Sho‐ichi Yamagishi, Hiroyuki Tanaka
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
advanced glycation end products
aortic valve stenosis
atherosclerosis
calcification
inflammation
receptor for advanced glycation end products
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.015261

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https://www.ahajournals.org/doi/10.1161/JAHA.119.015261

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