Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1−/− mice

Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1−/− mice

Summary: Mutations of the GABA-A receptor subunit β1 (GABRB1) gene are found in autism patients. However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated Gabrb1−/− mouse model, which showed autistic-like behaviors. We carried out RNA-seq on the hippocampus and found gluta...

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Bibliographic Details
Main Authors: Jing Wang, Yue Gao, Liuyan Xiao, Yanmei Lin, Lang Huang, Jinfa Chen, Guanmei Liang, Weiming Li, Wenjuan Yi, Jianpei Lao, Bin Zhang, Tian-Ming Gao, Mei Zhong, Xinping Yang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Neuroscience
Behavioral neuroscience
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015535

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http://www.sciencedirect.com/science/article/pii/S2589004223015535

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