Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease

Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease

The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied behavioral phenotype parameters, including spatial learning and memory (Morris Water Maz...

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Bibliographic Details
Main Authors: Sudhir Kshirsagar, Rainier Vladlen Alvir, Ashly Hindle, Subodh Kumar, Murali Vijayan, Jangampalli Adi Pradeepkiran, Arubala P. Reddy, Bhagavathi Ramasubramanian, P. Hemachandra Reddy
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
amyloid beta
mitochondria
late-onset Alzheimer’s disease
dendritic spines
Online Access:https://www.mdpi.com/2073-4409/11/4/733

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https://www.mdpi.com/2073-4409/11/4/733

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