BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source of ESCs and show nucleosome remodelers Smarcc1 and Sm...

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Bibliographic Details
Main Authors: Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29333-1

Internet

https://doi.org/10.1038/s41467-022-29333-1

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