Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

Previous studies provided evidence for the alteration of brain cholesterol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome. The efficacy of statins in improving motor symptoms and prolonging survival of mutant mice suggested a potential role of statins in the therapy of Re...

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Bibliographic Details
Main Authors: Claudia Villani, Giuseppina Sacchetti, Renzo Bagnati, Alice Passoni, Federica Fusco, Mirjana Carli, Roberto William Invernizzi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
Rett syndrome
lovastatin
24S-hydroxycholesterol
genetic background
cholesterol metabolism
Mecp2
Online Access:https://elifesciences.org/articles/22409

Internet

https://elifesciences.org/articles/22409

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