The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study.

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study.

Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications. To be biologically active, such an oligonucleotide has to efficiently bind the target sequence. Here we used molecular dynamics...

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Bibliographic Details
Main Authors: You Xu, Olof Gissberg, Y Vladimir Pabon-Martinez, Jesper Wengel, Karin E Lundin, C I Edvard Smith, Rula Zain, Lennart Nilsson, Alessandra Villa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211651

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https://doi.org/10.1371/journal.pone.0211651

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