Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders
Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a n...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-11-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02649-2 |
| _version_ | 1827708162848849920 |
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| author | Trine Munk-Olsen Arianna Di Florio Kathrine B. Madsen Clara Albiñana Merete L. Mægbæk Veerle Bergink Vibe G. Frøkjær Esben Agerbo Bjarni J. Vilhjálmsson Thomas Werge Merete Nordentoft David M. Hougaard Anders D. Børglum Ole Mors Preben Bo Mortensen Xiaoqin Liu |
| author_facet | Trine Munk-Olsen Arianna Di Florio Kathrine B. Madsen Clara Albiñana Merete L. Mægbæk Veerle Bergink Vibe G. Frøkjær Esben Agerbo Bjarni J. Vilhjálmsson Thomas Werge Merete Nordentoft David M. Hougaard Anders D. Børglum Ole Mors Preben Bo Mortensen Xiaoqin Liu |
| author_sort | Trine Munk-Olsen |
| collection | DOAJ |
| description | Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0 .97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account. |
| first_indexed | 2024-03-10T16:59:49Z |
| format | Article |
| id | doaj.art-55dd8d9090d14f2ea460f664133aba97 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-03-10T16:59:49Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-55dd8d9090d14f2ea460f664133aba972023-11-20T11:00:28ZengNature Publishing GroupTranslational Psychiatry2158-31882023-11-011311710.1038/s41398-023-02649-2Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disordersTrine Munk-Olsen0Arianna Di Florio1Kathrine B. Madsen2Clara Albiñana3Merete L. Mægbæk4Veerle Bergink5Vibe G. Frøkjær6Esben Agerbo7Bjarni J. Vilhjálmsson8Thomas Werge9Merete Nordentoft10David M. Hougaard11Anders D. Børglum12Ole Mors13Preben Bo Mortensen14Xiaoqin Liu15NCRR-The National Centre for Register-based Research, Aarhus UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityNCRR-The National Centre for Register-based Research, Aarhus UniversityNCRR-The National Centre for Register-based Research, Aarhus UniversityNCRR-The National Centre for Register-based Research, Aarhus UniversityDepartment of Psychiatry, Erasmus Medical Centre RotterdamDepartment of Neurology and Neurobiology Research Unit, Copenhagen University HospitalNCRR-The National Centre for Register-based Research, Aarhus UniversityNCRR-The National Centre for Register-based Research, Aarhus UniversityiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric ResearchiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric ResearchiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric ResearchiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric ResearchiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric ResearchNCRR-The National Centre for Register-based Research, Aarhus UniversityNCRR-The National Centre for Register-based Research, Aarhus UniversityAbstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0 .97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account.https://doi.org/10.1038/s41398-023-02649-2 |
| spellingShingle | Trine Munk-Olsen Arianna Di Florio Kathrine B. Madsen Clara Albiñana Merete L. Mægbæk Veerle Bergink Vibe G. Frøkjær Esben Agerbo Bjarni J. Vilhjálmsson Thomas Werge Merete Nordentoft David M. Hougaard Anders D. Børglum Ole Mors Preben Bo Mortensen Xiaoqin Liu Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders Translational Psychiatry |
| title | Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders |
| title_full | Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders |
| title_fullStr | Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders |
| title_full_unstemmed | Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders |
| title_short | Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders |
| title_sort | postpartum and non postpartum depression a population based matched case control study comparing polygenic risk scores for severe mental disorders |
| url | https://doi.org/10.1038/s41398-023-02649-2 |
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