Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Mutations in nuclear genes associated with defective coenzyme A biosynthesis have been identified as responsible for some forms of neurodegeneration with brain iron accumulation (NBIA), namely PKAN and CoPAN. PKAN are defined by mutations in PANK2, encoding the pantothenate kinase 2 enzyme...

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Bibliographic Details
Main Authors: Camilla Ceccatelli Berti, Cristina Dallabona, Mirca Lazzaretti, Sabrina Dusi, Elena Tosi, Valeria Tiranti, Paola Goffrini
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-04-01
Series:Microbial Cell
Subjects:
Saccharomyces cerevisiae
yeast model
Coenzyme A
NBIA
COASY
mitochondria
iron accumulation
lipid content
Online Access:http://microbialcell.com/researcharticles/modeling-human-coenzyme-a-synthase-mutation-in-yeast-reveals-altered-mitochondrial-function-lipid-content-and-iron-metabolism-2/

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http://microbialcell.com/researcharticles/modeling-human-coenzyme-a-synthase-mutation-in-yeast-reveals-altered-mitochondrial-function-lipid-content-and-iron-metabolism-2/

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