Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry

Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry

Abstract Background Identifying T cell epitopes on pancreatic ductal adenocarcinoma (PDAC) associated antigens or neoantigens has been a challenge. In this study, we attempted to identify PDAC T cell epitopes by mass spectrometry (MS). Methods We isolated HLA class I (HLA-I) and HLA class II (HLA-II...

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Bibliographic Details
Main Authors: Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Hematology & Oncology
Subjects:
Pancreatic ductal adenocarcinoma
Mass spectrometry
T cell epitopes
Peptidome analysis
Immunotherapy
Online Access:https://doi.org/10.1186/s13045-022-01373-6

Internet

https://doi.org/10.1186/s13045-022-01373-6

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