Location bias contributes to functionally selective responses of biased CXCR3 agonists

Location bias contributes to functionally selective responses of biased CXCR3 agonists

Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al. determine that agonist-biased CXCR3 signaling at endosomes differs from that at the plasma membrane, proposing location bias as an important phenomenon...

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Bibliographic Details
Main Authors: Dylan Scott Eiger, Noelia Boldizsar, Christopher Cole Honeycutt, Julia Gardner, Stephen Kirchner, Chloe Hicks, Issac Choi, Uyen Pham, Kevin Zheng, Anmol Warman, Jeffrey S. Smith, Jennifer Y. Zhang, Sudarshan Rajagopal
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33569-2

Internet

https://doi.org/10.1038/s41467-022-33569-2

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