Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α

Background/objective: Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development and its ligand transforming growth factor-α (TGFα) is upreg...

Full description

Bibliographic Details
Main Authors: Ermina Hadzic, Bethia To, Michael A. Pest, Ling Qin, Frank Beier
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Epidermal growth factor receptor
Mitogen inducible gene 6
Transgenic mice
Chondrocyte
Animal model
Transforming growth factor-alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913123000547

Internet

http://www.sciencedirect.com/science/article/pii/S2665913123000547

Similar Items