The Role of FAS Receptor Methylation in Osteosarcoma Metastasis

The Role of FAS Receptor Methylation in Osteosarcoma Metastasis

Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of FASL and its cell surface receptor, FAS, triggers...

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Bibliographic Details
Main Authors: Jiayi M. Sun, Wing-Yuk Chow, Gufeng Xu, M. John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing Ng, Aaron M. Taylor, Alexander Yu, Jason E. Farrar, Donald A. Barkauskas, Richard Gorlick, Jaime M. Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong Man, Ching C. Lau, on behalf of the TARGET Osteosarcoma Consortium
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
osteosarcoma
FAS receptor
DNA methylation
5-azacytidine
prognosis
Online Access:https://www.mdpi.com/1422-0067/24/15/12155

Internet

https://www.mdpi.com/1422-0067/24/15/12155

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