Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Introduction: Early identification of cardiac risk is essential for reducing late-stage attrition in drug development. We adapted the previously published cardiac hazard risk-scoring system using a calcium transient assay in human stem cell-derived CMs for the identification of cardiac risks recorde...

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Bibliographic Details
Main Authors: Hua Rong Lu, Mohamed Kreir, Van Ammel Karel, Fetene Tekle, Danny Geyskens, Ard Teisman, David J. Gallacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
stem cells
cardiomyocytes (hiPS-CMs)
cardiac hazard risk
HTS assay
translation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.838435/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.838435/full

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