VARSCOT: variant-aware detection and scoring enables sensitive and personalized off-target detection for CRISPR-Cas9

VARSCOT: variant-aware detection and scoring enables sensitive and personalized off-target detection for CRISPR-Cas9

Abstract Background Natural variations in a genome can drastically alter the CRISPR-Cas9 off-target landscape by creating or removing sites. Despite the resulting potential side-effects from such unaccounted for sites, current off-target detection pipelines are not equipped to include variant inform...

Full description

Bibliographic Details
Main Authors: Laurence O. W. Wilson, Sara Hetzel, Christopher Pockrandt, Knut Reinert, Denis C. Bauer
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Biotechnology
Subjects:
CRISPR-Cas9
Off-target detection
Variants
Genome editing
Online Access:http://link.springer.com/article/10.1186/s12896-019-0535-5

Internet

http://link.springer.com/article/10.1186/s12896-019-0535-5

Similar Items