Single-Cell Analyses of a Novel Mouse Urothelial Carcinoma Model Reveal a Role of Tumor-Associated Macrophages in Response to Anti-PD-1 Therapy

Single-Cell Analyses of a Novel Mouse Urothelial Carcinoma Model Reveal a Role of Tumor-Associated Macrophages in Response to Anti-PD-1 Therapy

Approximately 80% of patients with advanced bladder cancer do not respond to immune checkpoint inhibitor (ICI) immunotherapy. Therefore, there is an urgent unmet need to develop clinically relevant preclinical models so that factors governing immunotherapy responses can be studied in immunocompetent...

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Bibliographic Details
Main Authors: Dongbo Xu, Li Wang, Kyle Wieczorek, Yali Zhang, Zinian Wang, Jianmin Wang, Bo Xu, Prashant K. Singh, Yanqing Wang, Xiaojing Zhang, Yue Wu, Gary J. Smith, Kristopher Attwood, Yuesheng Zhang, David W. Goodrich, Qiang Li
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
single-cell analyses
mouse urothelial carcinoma
mouse model
ICI immunotherapy
anti-PD-1
tumor-associated macrophages
Online Access:https://www.mdpi.com/2072-6694/14/10/2511

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https://www.mdpi.com/2072-6694/14/10/2511

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