A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation
Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2012-11-01
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| Series: | Australasian Orthodontic Journal |
| Online Access: | https://doi.org/10.2478/aoj-2012-0020 |
| Summary: | Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of 2.5mg/kg.1,2 |
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| ISSN: | 2207-7480 |