A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation
Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2012-11-01
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| Series: | Australasian Orthodontic Journal |
| Online Access: | https://doi.org/10.2478/aoj-2012-0020 |
| _version_ | 1797752404883537920 |
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| author | Curl Linda Barker Christopher Dreyer Craig Sampson Wayne |
| author_facet | Curl Linda Barker Christopher Dreyer Craig Sampson Wayne |
| author_sort | Curl Linda |
| collection | DOAJ |
| description | Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of 2.5mg/kg.1,2 |
| first_indexed | 2024-03-12T17:03:54Z |
| format | Article |
| id | doaj.art-55fd8e8e29b34d51914be4885961844e |
| institution | Directory Open Access Journal |
| issn | 2207-7480 |
| language | English |
| last_indexed | 2024-03-12T17:03:54Z |
| publishDate | 2012-11-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Australasian Orthodontic Journal |
| spelling | doaj.art-55fd8e8e29b34d51914be4885961844e2023-08-07T06:57:55ZengSciendoAustralasian Orthodontic Journal2207-74802012-11-0128221922410.2478/aoj-2012-0020A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammationCurl Linda0Barker Christopher1Dreyer Craig2Sampson Wayne31Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, AustraliaBackground: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of 2.5mg/kg.1,2https://doi.org/10.2478/aoj-2012-0020 |
| spellingShingle | Curl Linda Barker Christopher Dreyer Craig Sampson Wayne A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation Australasian Orthodontic Journal |
| title | A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| title_full | A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| title_fullStr | A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| title_full_unstemmed | A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| title_short | A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| title_sort | pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation |
| url | https://doi.org/10.2478/aoj-2012-0020 |
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