Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell eliminatio...

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Bibliographic Details
Main Authors: Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath, Valery Krizhanovsky
Format: Article
Language:English
Published: Nature Portfolio 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11190

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https://doi.org/10.1038/ncomms11190

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