Disease-Causing Allele-Specific Silencing by RNA Interference

Disease-Causing Allele-Specific Silencing by RNA Interference

Small double-stranded RNAs (dsRNAs) of approximately 21-nucleotides in size, referred to as small interfering RNA (siRNA) duplexes, can induce sequence-specific posttranscriptional gene silencing, or RNA interference (RNAi). Since chemically synthesized siRNA duplexes were found to induce RNAi in ma...

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Bibliographic Details
Main Author: Hirohiko Hohjoh
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Pharmaceuticals
Subjects:
RNAi
allele-specific silencing
siRNA selection
dominantly inherited disease
nucleotide variation
allele discrimination
siRNA modification
forked siRNA
Online Access:http://www.mdpi.com/1424-8247/6/4/522

Internet

http://www.mdpi.com/1424-8247/6/4/522

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