Open Reading Frame 4 Is Not Essential in the Replication and Infection of Genotype 1 Hepatitis E Virus

Genotype 1 hepatitis E virus (HEV-1), unlike other genotypes of HEV, has a unique small open reading frame known as ORF4 whose function is not yet known. ORF4 is located in an out-framed manner in the middle of ORF1, which encodes putative 90 to 158 amino acids depending on the strains. To explore t...

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Bibliographic Details
Main Authors: Huimin Bai, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Masamichi Muramatsu, Tian-Cheng Li
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/3/784