Crucial Role of Stromal Interaction Molecule-Activated TRPC-ORAI Channels in Vascular Remodeling and Pulmonary Hypertension Induced by Intermittent Hypoxia

Crucial Role of Stromal Interaction Molecule-Activated TRPC-ORAI Channels in Vascular Remodeling and Pulmonary Hypertension Induced by Intermittent Hypoxia

Obstructive sleep apnea (OSA), a sleep breathing disorder featured by chronic intermittent hypoxia (CIH), is associate with pulmonary hypertension. Rats exposed to CIH develop lung vascular remodeling and pulmonary hypertension, which paralleled the upregulation of stromal interaction molecule (STIM...

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Bibliographic Details
Main Authors: Sebastián Castillo-Galán, Bárbara Riquelme, Rodrigo Iturriaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Physiology
Subjects:
2-APB
STIM-activated TRPC-ORAI channels
chronic intermittent hypoxia
pulmonary hypertension
pulmonary vascular remodeling
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.841828/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.841828/full

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