High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of chemically distinct lipid libraries poses a signific...

Full description

Bibliographic Details
Main Authors: Lulu Xue, Alex G. Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G. Figueroa-Espada, Sarah J. Shepherd, Alvin J. Mukalel, Mohamad-Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E. Vaughan, Drew Weissman, Michael J. Mitchell
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45422-9

Internet

https://doi.org/10.1038/s41467-024-45422-9

Similar Items