LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome

LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome

Background LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, wh...

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Bibliographic Details
Main Authors: Raquel Malumbres, Vicente Fresquet, Jose Roman-Gomez, Miriam Bobadilla, Eloy F. Robles, Giovanna G. Altobelli, M.ª José Calasanz, Erlend B. Smeland, Maria Angela Aznar, Xabier Agirre, Vanesa Martin-Palanco, Felipe Prosper, Izidore S. Lossos, Jose A. Martinez-Climent
Format: Article
Language:English
Published: Ferrata Storti Foundation 2011-07-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/6027

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https://haematologica.org/article/view/6027

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