Peptidomimetics Based on <i>C</i>-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins

Peptidomimetics Based on <i>C</i>-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins

Degradation of misfolded, redundant and oxidatively damaged proteins constitutes one of the cellular processes which are influenced by the 20S proteasome. However, its activity is generally thought to decrease with age which leads to the gradual accumulation of abnormal proteins in cells and their s...

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Bibliographic Details
Main Authors: Katarzyna Cekała, Karolina Trepczyk, Daria Sowik, Przemysław Karpowicz, Artur Giełdoń, Julia Witkowska, Małgorzata Giżyńska, Elżbieta Jankowska, Ewa Wieczerzak
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomolecules
Subjects:
proteasome
activation
20S
neurodegenerative diseases
microscale thermophoresis
Online Access:https://www.mdpi.com/2218-273X/12/6/777

Internet

https://www.mdpi.com/2218-273X/12/6/777

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