Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.

AIMS: Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM). METHODS AND RESULTS: Al...

Full description

Bibliographic Details
Main Authors: Laura Novensà, Susana Novella, Pascual Medina, Gloria Segarra, Nadia Castillo, Magda Heras, Carlos Hermenegildo, Ana Paula Dantas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3178641?pdf=render

Internet

http://europepmc.org/articles/PMC3178641?pdf=render

Similar Items