Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

Abstract Cryo-transmission electron microscopy (cryo-EM) of frozen hydrated specimens is an efficient method for the structural analysis of purified biological molecules. However, cryo-EM and cryo-electron tomography are limited by the low signal-to-noise ratio (SNR) of recorded images, making detec...

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Bibliographic Details
Main Authors: Berk Küçükoğlu, Inayathulla Mohammed, Ricardo C. Guerrero-Ferreira, Stephanie M. Ribet, Georgios Varnavides, Max Leo Leidl, Kelvin Lau, Sergey Nazarov, Alexander Myasnikov, Massimo Kube, Julika Radecke, Carsten Sachse, Knut Müller-Caspary, Colin Ophus, Henning Stahlberg
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52403-5

Internet

https://doi.org/10.1038/s41467-024-52403-5

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