Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway

Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway

Renal tubulointerstitial fibrosis (TIF), characterized by epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic nephropathy. Gentiopicroside (GPS), a natural compound with anti-inflammatory activity, has been demonstrated to...

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Bibliographic Details
Main Authors: Zhanchi Xu, Meng Zhang, Yu Wang, Rui Chen, Shiyue Xu, Xiaohong Sun, Yan Yang, Zeyuan Lin, Shaogui Wang, Heqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
tubulointerstitial fibrosis
AT1R
CK2/NF-κB pathway
gentiopicroside
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.848915/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.848915/full

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