The function of the gut microbiota–bile acid–TGR5 axis in diarrhea-predominant irritable bowel syndrome

The function of the gut microbiota–bile acid–TGR5 axis in diarrhea-predominant irritable bowel syndrome

ABSTRACTImbalanced gut microbiota (GM) and abnormal fecal bile acid (BA) are thought to be the key factors for diarrhea-predominant irritable bowel syndrome (IBS-D), but the underlying mechanism remains unclear. Herein, we explore the influence of the GM–BA–Takeda G-protein-coupled receptor 5 (TGR5)...

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Bibliographic Details
Main Authors: Kai Zhan, Haomeng Wu, Yongyin Xu, Kehan Rao, Huan Zheng, Shumin Qin, Yuanming Yang, Rui Jia, Weihuan Chen, Shaogang Huang
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mSystems
Subjects:
diarrhea-predominant irritable bowel syndrome
gut microbiota
bile acid
TGR5
Online Access:https://journals.asm.org/doi/10.1128/msystems.01299-23

Internet

https://journals.asm.org/doi/10.1128/msystems.01299-23

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