Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4

Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4

Abstract Interaction between tumor cells and tumor microenvironment (TME) is critical to promote tumor progression and metastasis. As the most abundant immune cells in TME, macrophages can be polarized into M2-like tumor-associated macrophages (TAMs) which further promote tumor progression. However,...

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Bibliographic Details
Main Authors: Yang Zheng, Shuguang Ren, Yu Zhang, Sihua Liu, Lingjiao Meng, Fei Liu, Lina Gu, Ning Ai, Meixiang Sang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cancer Cell International
Subjects:
Breast cancer
Tumor-associated macrophages
circWWC3
IL-4
PD-L1
Online Access:https://doi.org/10.1186/s12935-022-02686-9

Internet

https://doi.org/10.1186/s12935-022-02686-9

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