Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight

Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight

Abstract Microphysiological systems provide the opportunity to model accelerated changes at the human tissue level in the extreme space environment. Spaceflight-induced muscle atrophy experienced by astronauts shares similar physiological changes to muscle wasting in older adults, known as sarcopeni...

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Bibliographic Details
Main Authors: Maddalena Parafati, Shelby Giza, Tushar S. Shenoy, Jorge A. Mojica-Santiago, Meghan Hopf, Legrand K. Malany, Don Platt, Isabel Moore, Zachary A. Jacobs, Paul Kuehl, Jason Rexroat, Gentry Barnett, Christine E. Schmidt, William T. McLamb, Twyman Clements, Paul M. Coen, Siobhan Malany
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-023-00322-y

Internet

https://doi.org/10.1038/s41526-023-00322-y

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