Dexmedetomidine and Ketamine Attenuated Neuropathic Pain Related Behaviors via STING Pathway to Induce ER-Phagy

Dexmedetomidine and Ketamine Attenuated Neuropathic Pain Related Behaviors via STING Pathway to Induce ER-Phagy

Our previous work indicated that ER-phagy level had altered in spinal nerve ligation (SNL) rats. In this study, we investigated whether dexmedetomidine or ketamine exhibits anti-anxiety or anti-nociceptive effects via modulation of the spinal STING/TBK pathway to alter ER-phagy in SNL rats. We evalu...

Full description

Bibliographic Details
Main Authors: Yongda Liu, Shihui Kuai, Mengmeng Ding, Zhibin Wang, Limei Zhao, Ping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
neuropathic pain
endoplasmic reticulum stress
autophagy
ketamine
dexmedetomidine
STING pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2022.891803/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsyn.2022.891803/full

Similar Items