(Dys)function Follows Form: Nucleic Acid Structure, Repeat Expansion, and Disease Pathology in <i>FMR1</i> Disorders

(Dys)function Follows Form: Nucleic Acid Structure, Repeat Expansion, and Disease Pathology in <i>FMR1</i> Disorders

Fragile X-related disorders (FXDs), also known as <i>FMR1</i> disorders, are examples of repeat expansion diseases (REDs), clinical conditions that arise from an increase in the number of repeats in a disease-specific microsatellite. In the case of FXDs, the repeat unit is CGG/CCG and th...

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Bibliographic Details
Main Authors: Xiaonan Zhao, Karen Usdin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
fragile X-associated primary ovarian insufficiency (FXPOI)
fragile X-associated tremor/ataxia syndrome (FXTAS)
fragile X syndrome (FXS)
repeat instability
repeat expansion
chromosome fragility
Online Access:https://www.mdpi.com/1422-0067/22/17/9167

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https://www.mdpi.com/1422-0067/22/17/9167

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