Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation.

Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation.

Long QT syndrome (LQTS) leads to arrhythmic events and increased risk for sudden cardiac death (SCD). Homozygous KCNH2 mutations underlying LQTS-2 have previously been termed "human HERG knockout" and typically express severe phenotypes. We studied genotype-phenotype correlations of an LQT...

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Bibliographic Details
Main Authors: Ulrich Schweigmann, Peter Biliczki, Rafael J Ramirez, Christoph Marschall, Ina Takac, Ralf P Brandes, Dieter Kotzot, Zenawit Girmatsion, Stefan H Hohnloser, Joachim R Ehrlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4139196?pdf=render

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http://europepmc.org/articles/PMC4139196?pdf=render

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