1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

Background Epidemiological surveys have revealed that low serum vitamin D level was correlated with increased risk of tumors. Dysfunctional T cells in patients with tumor are characterized as exhausted with high levels of immune checkpoint receptors (ICRs). However, whether the reduced level of vita...

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Bibliographic Details
Main Authors: Peng Li, Hua Zhang, Xiao Wang, Biyun Chen, Ke Li, Zhinan Yin, Xinhai Zhu, Guangchao Cao, Ruan Wu, Wenhui Yuan, Guodong Sun, Xichun Xia, Ligong Lu, Yunfei Gao
Format: Article
Language:English
Published: BMJ Publishing Group 2022-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/3/e003477.full

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https://jitc.bmj.com/content/10/3/e003477.full

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