Analysis of the Circulating Metabolome of Patients with Cutaneous, Mucosal and Uveal Melanoma Reveals Distinct Metabolic Profiles with Implications for Response to Immunotherapy

Analysis of the Circulating Metabolome of Patients with Cutaneous, Mucosal and Uveal Melanoma Reveals Distinct Metabolic Profiles with Implications for Response to Immunotherapy

Cutaneous melanoma (CM) patients respond better to immune checkpoint inhibitors (ICI) than mucosal and uveal melanoma patients (MM/UM). Aiming to explore these differences and understand the distinct response to ICI, we evaluated the serum metabolome of advanced CM, MM, and UM patients. Levels of 11...

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Bibliographic Details
Main Authors: Maysa Vilbert, Erica C. Koch, April A. N. Rose, Rob C. Laister, Diana Gray, Valentin Sotov, Susanne Penny, Anna Spreafico, Devanand M. Pinto, Marcus O. Butler, Samuel D. Saibil
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
melanoma
cutaneous melanoma
mucosal melanoma
uveal melanoma
immune-checkpoint inhibitors
metabolomics
Online Access:https://www.mdpi.com/2072-6694/15/14/3708

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https://www.mdpi.com/2072-6694/15/14/3708

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