Mitochondrial Genetic Heterogeneity in Leber’s Hereditary Optic Neuropathy: Original Study with Meta-Analysis

Mitochondrial Genetic Heterogeneity in Leber’s Hereditary Optic Neuropathy: Original Study with Meta-Analysis

Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disorder that causes loss of central vision. Three primary variants (m.3460G>A, m.11778G>A, and m.14484T>C) and about 16 secondary variants are responsible for LHON in the majority of the cases. We investigated the complete mitoc...

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Bibliographic Details
Main Authors: Rajan Kumar Jha, Chhavi Dawar, Qurratulain Hasan, Akhilesh Pujar, Gaurav Gupta, Venugopalan Y. Vishnu, Ramesh Kekunnaya, Kumarasamy Thangaraj
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Genes
Subjects:
LHON
mtDNA
meta-analysis
haplogroup
primary variants
DNA sequencing
Online Access:https://www.mdpi.com/2073-4425/12/9/1300

Internet

https://www.mdpi.com/2073-4425/12/9/1300

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