Characterization of an Italian founder mutation in the RING-finger domain of BRCA1.

Characterization of an Italian founder mutation in the RING-finger domain of BRCA1.

The identification of founder mutations in cancer predisposing genes is important to improve risk assessment in geographically defined populations, since it may provide specific targets resulting in cost-effective genetic testing. Here, we report the characterization of the BRCA1 c.190T>C (p.Cys6...

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Bibliographic Details
Main Authors: Laura Caleca, Anna Laura Putignano, Mara Colombo, Caterina Congregati, Mohosin Sarkar, Thomas J Magliery, Carla B Ripamonti, Claudia Foglia, Bernard Peissel, Daniela Zaffaroni, Siranoush Manoukian, Carlo Tondini, Monica Barile, Valeria Pensotti, Loris Bernard, Laura Papi, Paolo Radice
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3916327?pdf=render

Internet

http://europepmc.org/articles/PMC3916327?pdf=render

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