Cerebellar associative sensory learning defects in five mouse autism models

Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2−/−, L7-Tsc1 (L7/Pcp2Cre::Tsc1flox/+), and patDp(15q11-13)/+, we report specific perturbations in de...

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Bibliographic Details
Main Authors: Alexander D Kloth, Aleksandra Badura, Amy Li, Adriana Cherskov, Sara G Connolly, Andrea Giovannucci, M Ali Bangash, Giorgio Grasselli, Olga Peñagarikano, Claire Piochon, Peter T Tsai, Daniel H Geschwind, Christian Hansel, Mustafa Sahin, Toru Takumi, Paul F Worley, Samuel S-H Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/06085